Method and compositions for making ACSF and ACSF antagonists

Details Method and compositions for making ACSF and ACSF antagonists Method and compositions for making ACSF and ACSF antagonists

1994-01-04

1997-09-16

Hutzell, Paula

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 2, 530300, 530324, 4241931, A61K 3816

Patent

active

056681062

ABSTRACT:
The complete amino acid and nucleotide sequence for adenylate cyclase stimulating factor is provided, thereby facilitating the synthesis of ACSF in recombinant cell culture. ACSF amino acid sequence variants and ACSF antibodies are provided which are useful in the treatment of humoral hypercalcemia of malignancy or in immunoassays for ACSF. In particular, antibodies capable of binding only the C-terminal domains of ACSF are useful in immunoassays for ACSF which avoid interference by parathyroid hormone. Also provided are novel polypeptides selected from the group of the ACSF basic peptide, the ACSF C-terminal peptide, or the ACSF domain containing both of the basic and C-terminal peptides.

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