Process for preparing cyclic ketones

Details Process for preparing cyclic ketones Process for preparing cyclic ketones

1994-11-04

1996-02-06

Reamer, James H.

Organic compounds -- part of the class 532-570 series

Organic compounds

Oxygen containing

568314, C07C 4545

Patent

active

054897122

ABSTRACT:
The present invention provides a novel process for preparing cyclic ketones, such as indanones, which comprises the steps of (a) subjecting a substituted ketone to suitable methylenation conditions in the presence of a methylene transfer agent and an acylating agent for a sufficient period of time and under suitable conditions of temperature and pressure to form the corresponding alpha, beta unsaturated ketone, and (b) subjecting said unsaturated ketone to suitable cyclization conditions in the presence of a suitable acid or base for a sufficient period of time and under suitable conditions of temperature and pressure to form said cyclic ketones.

REFERENCES:
patent: 3974212 (1976-08-01), Cragoe et al.
patent: 4070539 (1978-01-01), Cragoe et al.
patent: 4096267 (1978-06-01), Cragoe et al.
patent: 5021522 (1991-06-01), Durairaj et al.
patent: 5206289 (1993-04-01), Sinsky et al.
Ali et al, Chem. Abst., vol. 114, #143,073j (1991).

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