Antiarrhythmic tetrahydronaphthalene derivatives

Details Antiarrhythmic tetrahydronaphthalene derivatives Antiarrhythmic tetrahydronaphthalene derivatives

1980-10-09

1981-11-24

Raymond, Richard

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

260239BC, 260239BF, 26032625, 260330, 260333, 424246, 42424854, 424250, 424267, 424270, 424272, 424273R, 424274, 424275, 424285, 424324, 544 13, 544 54, 544 584, 544 79, 544238, 544335, 544357, 546189, 548200, 548214, 548215, 548240, 548300, 548356, A61K 31165, A61K 31535, C07C10329, C07C10385

Patent

active

043024530

ABSTRACT:
Compounds are provided having the structure ##STR1## wherein R.sup.1 and R.sup.2 may be the same or different and are hydrogen, lower alkyl, lower alkenyl, or hydroxy-lower alkyl, or R.sup.1 and R.sup.2 together with the nitrogen atom to which they are attached also form a heterocyclic radical which may contain another heteroatom, namely nitrogen, oxygen or sulfur; R.sup.3 and R.sup.4 may be the same or different and are hydrogen or lower alkyl. These compounds are useful in the treatment or arrhythmia.
In addition, novel intermediates are provided having the structure ##STR2## wherein R is hydrogen, benzyl or ##STR3## These intermediates are also useful in treating acute myocardial infarction.

REFERENCES:
patent: 4165384 (1979-08-01), Carlsson et al.
Borowitz et al., Organic Preparations and Procedures Int., 9(6), (1977), pp. 257-262.
Condon et al., J. Med. Chem., vol. 21, (1978), p. 913.
Weiss, Synthetic Ionophores, Yeshiva University, Ph.D., (1976).

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