Vaccine for vesicular stomatitis virus

Details Vaccine for vesicular stomatitis virus Vaccine for vesicular stomatitis virus

1984-08-30

1988-04-19

Moskowitz, Margaret

Drug, bio-affecting and body treating compositions

Lymphokine

424 93, 435 70, 4351723, 435320, 435235, 935 12, 935 32, 935 57, 935 65, A61K 3912, C12N 100, C12N 1500, C12N 700

Patent

active

047388463

ABSTRACT:
Synthetic vaccines for both the Indiana and New Jersey serotypes of vesicular stomatitis virus are provided. Recombinant vaccinia viruses are created with DNA sequences which encode antigenically active VSV proteins. Vaccinia virus sequences are inserted in plasmids and DNA sequences corresponding to encoding portions of the VSV genome are inserted into the plasmids with flanking vaccinia virus sequences. In cells transformed with such plasmids and also infected with vaccinia virus, homologous recombination occurs, producing the modified vaccinia viruses which act as vaccines encoding VSV proteins and inducing anti-VSV immune responses in inoculated animals.

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patent: 4603112 (1986-07-01), Paoletti
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Sprague, J. et al, Journal of Virology, 45: 773-781 (2-1983).
Panicalli, D. et al, Proc. Natl. Acad. Sci. USA, 80:5364-5368 (9-1983).
Mackett, M. et al, Journal of Virology, 49(3):857-864 (3-1984).
Paoletti, E. et al, Modern Approaches to Vaccines, Cold Spring Harbor Laboratory, R. M. Chanock et al, eds (1984), pp. 295-299.
Mackett, M. et al, Ibid, pp. 301-305.
Smith, G. L. et al, Ibid, pp. 313-317.
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