Composition for treatment of abnormal conditions of the epitheli

Details Composition for treatment of abnormal conditions of the epitheli Composition for treatment of abnormal conditions of the epitheli

1993-07-06

1996-02-06

Bawa, Raj

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Implant or insert

424 45, 424 49, 424 52, 424 53, 424 57, 424 7802, 424427, 424434, 424437, 424430, 424661, 424673, 424676, 424DIG15, 514944, 514945, 514966, 514967, 514968, A61K 900, A61K 3300

Patent

active

054894352

ABSTRACT:
A stable solution, cream, salve, or spray composition containing activated stabilized chlorine dioxide and phosphates, such as disodium hydrogen phosphate, sodium dihydrogen phosphate, trisodium phosphate, and sodium monofluorophosphate, is disclosed for the prevention and treatment of abnormal conditions of the epithelium of bodily orifices. Examples of such abnormal conditions of the epithelium of the rectal, vaginal, urethral, oral, nasal, ocular, and auditory canal orifices include bacterial infections, such as Actinobacillus actinomycetemcomitans and Porphyromonas gingivalis, and fungal infections, such as Candida, and leukoplakia. The preferred concentration ranges are between about 0.005%-2.0% chlorine dioxide, and between about 0.02%-3.0% phosphate. The phosphate compound retards escape of chlorine dioxide in the pH range of 6.0 to 7.4, at which pH stabilized chlorine dioxide becomes activated and releases sufficient chlorine dioxide to reduce motility and become lethal to the involved micro-organisms.

REFERENCES:
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patent: 4818519 (1989-04-01), Ratcliff
patent: 5200171 (1993-04-01), Ratcliff
"Storage of Chlorine Dioxide", by W. J. Masschelein, Ann Arbor Science Publishers, Inc., 1979, pp. 138-140 and footnotes 110 to 116.
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Perry A. Ratcliff, "Pathogenesis of a Pocket Re-Visited Porphyromonas Gingivalis Invasion of Gingiva", Periogram, Jun. 1993, update Foundation, Inc., Scottsdale, Arizona.

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