1,4-dihydropyridine 3,5 carboxyl compounds

Details 1,4-dihydropyridine 3,5 carboxyl compounds 1,4-dihydropyridine 3,5 carboxyl compounds

1993-05-10

1994-08-09

Ivy, C. Warren

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

546321, C07D21302

Patent

active

053367740

ABSTRACT:
A 1,4-dihydropyridine derivative represented by formula (I): ##STR1## wherein X represents an alkyl group, or a group of ##STR2## in which R.sub.1, R.sub.2, and R.sub.3 may be the same or different and each represent a hydrogen atom, a halogen atom, a nitro group, a nitrile group, or a trifluoromethyl group; R.sub.4 represents a substituted or unsubstituted acyloxymethyl group, an alkoxycarbonyloxymethyl group, a (2-oxo-1,3-dioxolen-4-yl)methyl group, a (5-substituted-2-oxo-1,3-dioxolen-4-yl)methyl group, or an acyl group; R.sub.5 represents a lower alkyl group or a substituted alkyl group; and R.sub.6 represents a hydrogen atom, a lower alkoxymethyl group, or a lower acyloxymethyl group, is disclosed.

REFERENCES:
Cambou et al, Biotechnology and Bioengineering, vol. XXVI, pp. 1449-1454 (1984).
Kajino et al, Chem. Pharm. Bull, vol. 37 pp. 2225-2228, (1989).
Tamazawa et al, J. Med. Chem., vol. 29, pp. 2504-2511, (1986).
Holdgun et al, Tetrahedron Letters, vol. 32, No. 29, pp. 3465-3468 (Jul. 15, 1991).
Conrad et al, Encyclopedia of Polymer Science & Technology, vol. 6, p. 49, 1964.
Tamazawa et al., J. Med. Chem., vol. 29, pp. 2504-2511 (1986).
Cambou et al., Biotechnology & Bioengineering, vol. XXVI, pp. 1449-1454 (1984).
Kajino et al., Chem. Pharm. Bull., vol. 37, No. 8, pp. 2225-2228 (1989).

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