2'-deamino-2'-hydroxyistamycin B.sub.o derivatives of low toxici

Details 2'-deamino-2'-hydroxyistamycin B.sub.o derivatives of low toxici 2'-deamino-2'-hydroxyistamycin B.sub.o derivatives of low toxici

1987-03-04

1989-01-03

Brown, J. R.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

536 161, 536 168, A61K 3170, C07H 1522

Patent

active

047957433

ABSTRACT:
As new 2'-deamino-2'-hydroxyistamycin B.sub.o derivatives are provided four compounds, namely 2'-deamino-2'-hydroxyistamycin B; 2'-deamino-2'-hydroxy-3-O-demethylistamycin B; 4-N-(.beta.-alanyl)-2'-deamino-2'-hydroxyistamycin B.sub.o ; and 4-N-(.beta.-alanyl)-2'-deamino-2'-hydroxy-3-O-demethylistamycin B.sub.o which all exhibit high antibacterial activity and low acute toxicity in combination. These new compounds are useful as antibacterial agent.

REFERENCES:
patent: 4296106 (1981-10-01), Umezawa et al.
patent: 4472388 (1984-09-01), Umezawa et al.

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