Preparation of 2-methylene-1,3-propanediamide by a fluoride anio

Details Preparation of 2-methylene-1,3-propanediamide by a fluoride anio Preparation of 2-methylene-1,3-propanediamide by a fluoride anio

1980-01-07

1981-07-14

Demers, Arthur P.

Organic compounds -- part of the class 532-570 series

Organic compounds

Amino nitrogen containing

556419, C07C10200, C07F 708

Patent

active

042788145

ABSTRACT:
A process for preparing 2-methylene-1,3-propanediamide is disclosed which comprises providing a solution of a compound of the formula ##STR1## wherein R.sub.1, R.sub.2, and R.sub.3 can each independently be lower alkyl of from 1 to 10 carbon atoms, aryl, alkaryl, aralkyl, or halogen and X is an electron-accepting leaving group, in an inert, aprotic organic solvent, and subjecting the compound in solution to fluoride anion to effect elimination of the silyl group ##STR2## and the electron-accepting leaving group

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Chan et al. Tet. Lett. 1974 #39 p. 3511.

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