Substituted 1-azaspiro[4,5]decanes and their analgesic compositi

Details Substituted 1-azaspiro[4,5]decanes and their analgesic compositi Substituted 1-azaspiro[4,5]decanes and their analgesic compositi

1983-02-09

1984-02-07

Bond, Robert T.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Parasitic organism or component thereof or substance...

424274, 548408, 546 16, C07D22120, A61K 31445

Patent

active

044303351

ABSTRACT:
This invention relates to substituted 1-azaspiro[4.5] decanes and 1-azaspiro[5.5]undecanes of the formula ##STR1## wherein R.sub.1 is hydrogen, --CO.sub.2 R.sub.4, R.sub.4 ; R.sub.2 is hydrogen, ##STR2## R.sub.3 is hydrogen, ##STR3## R.sub.4 is alkyl of 1 to 4 carbon atoms; R.sub.5 is alkyl of 1 to 8 carbon atoms; X is halogen, alkyl of 1 to 4 carbon atoms, alkoxy of 1 to 4 carbon atoms, CF.sub.3, and OH; m is an integer of 0, 1 or 2; and n is an integer of 1 or 2.

REFERENCES:
Schipper et al., "J. Organic Chemistry", vol. 26, pp. 4135-4137 (1961).
Rice "J. Medicinal Chemistry", vol. 8, pp. 825-830 (1965).

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