Redox amino acids and peptides containing them

Details Redox amino acids and peptides containing them Redox amino acids and peptides containing them

1995-02-28

1997-06-17

Ivy, C. Warren

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

546165, C07D21506, C07D21520, C07D21704

Patent

active

056398859

ABSTRACT:
The invention provides novel amino acids and peptides containing them which comprise a dihydropyridine.revreaction.pyridinium salt-type redox system and which provide site-specific and sustained delivery of pharmacologically active peptides to the brain. These new amino acids contain a redox system appended directly or via an alkylene bridge to the carbon atom adjacent to the carboxyl carbon and may be incorporated into a peptide chain at a variety of positions, including non-terminal positions.

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