Ocular hypotensive agent

Details Ocular hypotensive agent Ocular hypotensive agent

1994-07-01

1997-06-17

Ivy, C. Warren

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514395, 514510, 514559, 514560, 514569, 514577, A61K 3141, A61K 31415

Patent

active

056397739

ABSTRACT:
This invention relates to an ocular hypotensive agent which comprises a compound represented by the formula: ##STR1## wherein R.sup.1 represents hydrogen or an optionally substituted hydrocarbon residue that may be bound via a hetero atom; R.sup.2 represents hydrogen or a hydrocarbon residue that may have a substituent; R.sup.3 represents a group capable of forming an anion or a group capable of changing thereto; X is a covalent bond between the 2 benzene rings or a spacer having a chain length of 1 to 2 atoms as the linear moiety between the adjoining phenylene group and phenyl group; n represents 1 or 2; ring A is a benzene ring having 1 or 2 optional substituents in addition to the group represented by COOR.sup.2, or a pharmaceutically acceptable salt thereof.

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FASB J.S., A1218 (1991), S. Wilson et al., "The Ocular Hypotensive Effect of DUP 753, a Non-Peptide Agiotensin II Antagonist", p. 4918.
Curr. Eye Res., 8, 841-849 (1989), Mallorga et al., "Angiotensin II Receptors Labelled with .sup.125 I-[Sar.sup.1, Ile.sup.8 ] All in Abino Rabbit Ocular Tissues", pp. 841-849.
J. Ocular Pharmacol., 3, 295-307 (1988), Watkins et al.
Am. J. Ophthalmol., 105, 674-677 (1988), Constad et al.
Constad et al., "Use of an AngiotensinConverting Enzyme Inhibitor in Ocular Hypertension and Primary Open-Angle Glaucoma", American Journal of Ophthalmology, vol. 105:674-677, (1988).
Journal of Pharmacol. Exp. Ther., vol. 266(3), Kawamura et al., "TCV 116, a Novel Angiotensin II Receptor Antagonist . . . Carotid Injury in Rats", 1993, abstract.

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