Thiazolidine derivatives, their production and use

Details Thiazolidine derivatives, their production and use Thiazolidine derivatives, their production and use

1986-06-02

1988-10-04

Gerstl, Robert

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

548180, 548183, C07D41712, A61K 31425

Patent

active

047756870

ABSTRACT:
A thiazolidinedione derivative of the general formula: ##STR1## wherein X is an oxygen or sulfur atom, R.sup.1 and R.sup.2 each independently is hydrogen or a hydrocarbon residue which may optionally be substituted and R.sup.1 and R.sup.2 may jointly, together with the oxazole or thiazole ring, form a condensed ring and A is a lower alkylene group; or a salt thereof, are novel compounds, which exhibit in mammals blood sugar- and lipid-lowering activity, and are of value as a therapeutic agent for diabetes and/or therapeutic agent for hyperlipemia.

REFERENCES:
patent: 4287200 (1981-09-01), Kawamatsu et al.
patent: 4340605 (1982-07-01), Kawamatsu et al.
patent: 4461902 (1984-07-01), Kawamatsu et al.
patent: 4572912 (1986-02-01), Yoshioka
Sohda et al., Chem. Pharm. Bull., 30(10), 3563-3573, 3580-3600, (1982).
Fujita et al., Diabetes, vol. 32, 804-810, (1983).
Sohda et al., Chem. Pharm. Bull., 32(6), 2267-2278, (1984).

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