Imidazoquinolinylether derivatives useful as phosphodiesterase a

Details Imidazoquinolinylether derivatives useful as phosphodiesterase a Imidazoquinolinylether derivatives useful as phosphodiesterase a

1986-05-23

1988-10-04

Lee, Mary C.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

546 82, 544126, 544361, 514253, 5142328, C07D47104, C07D41314, C07D40114, A61K 3147

Patent

active

047756748

ABSTRACT:
Novel series of 2,3-dihydro-2-oxo-1H-imidazo[4,5-b]quinolinyl ether derivatives of formula ##STR1## wherein R.sub.1 is hydrogen, lower alkly, benzyl; R.sub.2 is hydrogen, halogen, lower alkyl, lower alkoxy; Alk is alkylene; Y is hydroxy and alkanoic or aralkanoic esters thereof, oxo ketone, dialkylamino, carboxylic acid and esters, carboxamides, alkoxy, ethanolamines and cyclic carbamates thereof, tetrazolyl, and optionally substituted phenylsulfonyl. The compounds are cyclic AMP phosphodiesterase inhibitors and are particularly useful as inhibitors of blood platelet aggregation and/or as cardiotonic agents.

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Fleming et al., New Drugs Annual: Cardiovascular Drugs, Raven Press, pp. 277-294, New York (1983).

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