Process for preparing 2,5-dibromopyrimidine

Details Process for preparing 2,5-dibromopyrimidine Process for preparing 2,5-dibromopyrimidine

1993-11-22

1994-12-06

Ford, John M.

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

C07D23930

Patent

active

053712242

ABSTRACT:
Process for preparing 2,5-dibromopyrimidine A process for preparing 2,5-dibromopyrimidine comprises reacting 5-bromo-2-chloropyrimidine with a solution of hydrogen bromide in a non-aqueous acid at a temperature of between 0.degree. and 120.degree. C.
The process can be carried out at low cost and gives high yields.

REFERENCES:
patent: 3280124 (1966-10-01), Boudakien et al.
patent: 4698091 (1987-10-01), Brunner et al.
J. Chem. Soc. Arantz et al., 1971, "Pryimidine Reactions. Part XXII. The Relative Reactivities of some Corresponding Chloro-, Bromo-, and Lodo-pyrimidines in Aminolysis", pp. 1889-1891.
J. Org. Chem., Crosby et al., Nov. 1960, "n-Butyl 5-Chloro-2-pyrimidoxyacetate-A Plant Growth Regulator Analog", pp. 1916-1919.
J. Chem. Soc., Hurst et al., 1967, "Pyrimidines. Part XVI. Syntheses of Bipyrimidinyls and of Halogeno- and Amidino-pyrimidines", pp. 1204-1209.
D. J. Brown, "The Chemistry of Heterocyclic Compounds", vol. 16, The Pyrimidines Supplement I, p. 10, published by Wiley-Interscience in 1970.
D. J. Brown, "The Chemistry of Heterocyclic Compounds", vol. 16, The Pyrimidines Supplement II, p. 11, published by Wiley-Interscience in 1985.
D. J. Brown, "The Chemistry of Heterocyclic Compounds", vol. 16, The Pyrimidines Supplement I, p. 10, published by Wiley-Interscience in 1970.
D. J. Brown, "The Chemistry of Heterocyclic Compounds", vol. 16, The Pyrimidines Supplement II, p. 11, published by Wiley-Interscience in 1985.

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