Dithiocompounds

Details Dithiocompounds Dithiocompounds

1979-11-29

1982-09-14

Randolph, John D.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

546275, 546278, 546290, A61K 31415, A61K 31425, A61K 3144, C07D49800

Patent

active

043495559

ABSTRACT:
Novel compounds of formula I ##STR1## are described wherein R is lower alkyl, phenyl or aralkyl of 7 to 12 carbon atoms, R.sup.1 is hydrogen, lower alkyl, hydroxyloweralkyl, loweralkoxyloweralkyl, lower alkoxy, halogen, formyl, phenyl, phenylalkyl or acetal [CH(OR.sup.2).sub.2 where R.sup.2 is lower alkyl, or two R.sup.4 radicals are joined to form a lower alkylene chain], m is 1 or 2, Z is an anion, A is an alkylene radical having from 1 to 3 carbon atoms, which may be substituted by lower alkyl of 1 to 6 carbon atoms, S is sulphur and X is a benzothiazole, benzimidazole, benzoxazole, or phenyl radical which may be substituted and acid addition or quaternary ammonium salts of compounds wherein X is a benzimidazole radical. The compounds are used for the treatment of ulcers or hypersecretion. Treatment methods are claimed as well as pharmaceutical compositions.

REFERENCES:
patent: 4177350 (1979-12-01), Zirngibl et al.
Renault et al., Chim. Ther., 1966, pp. 337-338.
Burger, Medicinal Chemistry, 2nd Ed., pp. 79-81, Interscience Pub. Co., NY (1960).
Renault et al., Chem. Abstracts, vol. 66, Abst. No. 55349p (1967) (abstract of R supra).

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