Preparation of piperidinylcyclopentylheptenoic acid derivatives

Details Preparation of piperidinylcyclopentylheptenoic acid derivatives Preparation of piperidinylcyclopentylheptenoic acid derivatives

1987-01-28

1989-05-30

Raymond, Richard L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

568838, 568772, 568830, C07D21134, C07C 3506, C07C 3700, C07C 29132

Patent

active

048352780

ABSTRACT:
A process is described for the preparation of a compound of formula (2) ##STR1## (wherein R is a C.sub.1-6 alkyl or a C.sub.7-20 aralkyl group) and the salts thereof, which comprises reducing a compound of formula (3) ##STR2## (or a salt thereof), using a reducing system comprising borohydride ions and metal ions selected from lanthanide ions, alkaline earth metal ions or yttrium ions in solution. The reduction system may be provided by a borohydride (e.g. NaBH.sub.4) and a metal salt (e.g. CeCl.sub.3).
The ester (2) may then if desired be hydrolyzed to give the parent acid.

REFERENCES:
patent: 4342756 (1982-08-01), Collington et al.
patent: 4409213 (1983-10-01), Collington et al.
patent: 4482549 (1984-11-01), Collington et al.
Andre L. Gemal et al., J. Am. Chem. Soc. (1981) vol. 103, pp. 5454-5459.

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