Process for the preparation of high-purity gamma- and alpha-cycl

Details Process for the preparation of high-purity gamma- and alpha-cycl Process for the preparation of high-purity gamma- and alpha-cycl

1987-07-09

1989-05-30

Robinson, Douglas W.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing compound containing saccharide radical

C12P 1918

Patent

active

048351059

ABSTRACT:
The invention relates to a process for the preparation of high-purity gamma- and alpha-cyclodextrin starting from a starch substrate of low reducing capacity, partially hydrolysed with alpha-amylase. According to the invention a starch substrate of low reducing capacity partially hydrolysed with alpha-amylase is converted with cyclodextrin glucosyl transferase, after the addition of an aliphatic ketone of the formula R.sub.1 COR.sub.2, in which R.sub.1 and R.sub.2 stand for a straight or branched chained alkyl group having from 1 to 6 carbon atoms, and/or a phenol derivative of the formula R.sub.3 R.sub.4 PheOH, wherein R.sub.3 and R.sub.4 are hydrogen, alkyl having from 1 to 4 carbon atoms, or R.sub.3 and R.sub.4 together form phenyl group, Phe stand for phenyl group, OH is hydroxyl and/or a benzene derivative of the formula R.sub.5 R.sub.6 Phe, wherein R.sub.5 and R.sub.6 are hydrogen, alkyl having from 1 to 4 carbon atoms, or R.sub.5 and R.sub.6 together form phenyl group, Phe is phenyl, as a precipitating agent, and if desired, alpha- and/or gamma-cyclodextrin is isolated from the conversion mixture in a crude form, or after further purification, in a pure form.

REFERENCES:
patent: 3425910 (1969-02-01), Armbruster et al.
patent: 3640847 (1972-02-01), Armbruster et al.
patent: 3652398 (1972-03-01), Armbruster et al.
patent: 3888738 (1975-06-01), Okada et al.
patent: 4384898 (1983-05-01), Okada et al.
patent: 4477568 (1984-10-01), Hokse et al.
Kitahata et al, Purification and Some Properties of Cyclodextrin Glycosyl Transferase from a Strain of Bacillus Species, Agr. Biol. Chem., 38, 2, pp. 387-393 (1974).

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