Human monoclonal antibodies to serotypic lipopolysaccharide dete

Details Human monoclonal antibodies to serotypic lipopolysaccharide dete Human monoclonal antibodies to serotypic lipopolysaccharide dete

1985-05-15

1989-05-30

Moskowitz, Margaret

Drug, bio-affecting and body treating compositions

Lymphokine

530387, 530388, 435 7, 435 68, 435 70, 4351722, 4351723, 4352402, 435948, 935100, 935107, 935 52, 935 71, 436548, A61K 3940, C07K 1500, C12N 500

Patent

active

048349755

ABSTRACT:
Transformed human lymphocyte cell lines have been produced which secrete human monoclonal antibodies to serotypic determinants on LPS molecules of gram-negative bacteria. These antibodies have been found to be protective against lethal challenges of the homologous bacteria. Pharmaceutical compositions containing these antibodies and their prophylactic and therapeutic use in the management of gram-negative disease in humans are also disclosed.

REFERENCES:
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