Controlled release pharmaceutical composition

Details Controlled release pharmaceutical composition Controlled release pharmaceutical composition

1987-11-12

1989-05-30

Davis, Curtis R.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Matrices

514488, A01N 2526, A61K 922

Patent

active

048349658

ABSTRACT:
A solid, controlled release pharmaceutical composition is provided with enhanced levels of control over drug release. The composition comprises an acid addition salt or a quarternary ammonium salt of an organic base drug complexed with an anionic surfactant and distributed in a matrix of a hydrophilic polymer. The complex formation between the drug which is preferably an acid addition salt of an organic an organic amine, and the surfactant, which is preferably a sulphosuccinate, distributed in the hydrophilic polymer matrix, which is preferably a water soluble hydroxyalkylcelulose ether results in a composition with excellent controlled released characteristics.

REFERENCES:
patent: 4540566 (1985-09-01), Davis et al.

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