Leukotriene-B4 derivatives, process for their production and the

Details Leukotriene-B4 derivatives, process for their production and the Leukotriene-B4 derivatives, process for their production and the

1991-03-25

1993-02-16

Killos, Paul J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

560126, 560127, 560231, 560254, 562507, 562508, 564 79, 564 80, 564 89, 564152, 564171, 568605, 568611, 568667, 568669, 568670, 568807, 568823, 568825, 568826, C07D31102, C07C 6702

Patent

active

051872862

ABSTRACT:
##STR1## Compounds of formula (I) in which the residues have the following meanings: a is (II) or (III); R.sup.1 is CH.sub.2 OH, CH.sub.3, CF.sub.3, COOR.sup.5 with R.sup.5 or, A is a trans, trans--CH.dbd.CH--CH.dbd.CH--or tetramethylene group; B is an alkylene group with up to 10 C atoms; D is a direct bond, oxygen, sulphur, a --C.tbd.C--group or a --CH.dbd.CR.sup.7 --group, or (IV); B and D together are a direct bond; R.sup.2 and R.sup.3 are the same or different and denote hydrogen or an organic acid residue with 1 to 15 C atoms, R.sup.1 and R.sup.2 together are a carbonyl group; R.sup.4 is a hydrogen atom or C.sub.1-10 alkyl, and if R.sup.5 denotes a hydrogen atom, their salts with physiologically acceptable bases and their cyclodextrin clathrates.

REFERENCES:
Morris J. et al. Tetrahedron Letters (29) No. 2 1988 pp. 143-146.
Borgeat et al., Prostaglandins 35 Nr. 5 May 1988 pp. 723-731.

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