Pharmaceutical compositions comprising quinazolin-4-one derivati

Details Pharmaceutical compositions comprising quinazolin-4-one derivati Pharmaceutical compositions comprising quinazolin-4-one derivati

1991-10-11

1993-02-16

Nutter, Nathan M.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514306, A01N 4348, A61K 31165

Patent

active

051871670

ABSTRACT:
A quinazoline of the formula:- ##STR1## wherein R.sup.1 is alkyl, cycloalkyl, alkenyl, alkynyl, alkoxy, alkylthio, aryl, aryloxy, arylalkyl, halogeno, hydroxy, mercapto, pyridylthio, pyrimidinylthio, or substituted alkyl or alkoxy;
wherein R.sup.2 is hydrogen, alkyl, alkenyl, alkynyl, substituted alkyl or alkanoyl;
wherein Ar is phenylene, naphthylene or heterocyclene which is unsubstituted or bears one or more substituents and wherein R.sup.3 is such that R.sup.3 --NH.sub.2 is an amino acid; or a pharmaceutically-acceptable salt or ester thereof. The compounds possess anti-tumor activity.

REFERENCES:
patent: 4564616 (1986-01-01), Jones et al.
Jones et al. in "Anticancer Quinazoline-Substituted Amino Acids", CA 106(13) 102,679c, May, 1986.

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