1-Oxo-2,2-disubstituted-5-indanyloxy(or thio)alkanoic acids

Details 1-Oxo-2,2-disubstituted-5-indanyloxy(or thio)alkanoic acids 1-Oxo-2,2-disubstituted-5-indanyloxy(or thio)alkanoic acids

1976-07-13

1978-04-18

Waddell, Frederick E.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Parasitic organism or component thereof or substance...

260308D, A61K 3145, C07D25704

Patent

active

040852199

ABSTRACT:
1-Oxo-2,2-disubstituted-5-indanyloxy(or thio)alkanoic acids and their salt, ester, anhydride, amide and 5-tetrazolyl derivatives are disclosed. The products display a dual pharmaceutical utility in that they exhibit diuretic, saluretic and uricosuric activity. The acid products are prepared by treating a 2,2-disubstituted-5-hydroxy(or mercapto)-1-indanone with an haloalkanoic acid or ester thereof and, if the ester is employed, hydrolyzing the ester.

REFERENCES:
patent: 3536715 (1970-10-01), Hayao et al.
patent: 3976686 (1976-08-01), Cragoe, Jr. et al.

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