Reactive alpha amino acid polymer

Details Reactive alpha amino acid polymer Reactive alpha amino acid polymer

1981-05-21

1983-05-24

Anderson, Harold D.

Synthetic resins or natural rubbers -- part of the class 520 ser

Synthetic resins

From carboxylic acid or derivative thereof

525420, 528328, C08G 6948, C08G 6910

Patent

active

043851690

ABSTRACT:
A reactive polymer having the degree of polymerization in the range of 5 to 3,000, with 60 mole % or more of the whole constituent units comprising the constituent units expressed by formula (I) ##STR1## wherein Z indicates a hydrogen atom or a univalent cation; m is an integer 1 to 4:
and has an active group expressed by formula (II) at the carboxyl end of the main chain ##STR2## wherein X indicates a hydrogen atom or a group which can form an active disulfide linkage together with a neighboring sulfur atom; W is a divalent organic group; and R.sub.1 represents a hydrogen atom or an alkyl group having 1 to 4 carbon atoms.
Since this reactive polymer can bind to cytotoxic substances, which contain an amino group or imino group in the molecule by way of the carboxyl group of the side chain and it also can bind to, for instance, antitumor immunoglobulins by way of an active group (thiol group or active disulfide group) at the end of the main chain, it can be used as a polymer carrier in the preparation of target seeking antitumor drugs.

REFERENCES:
patent: 4046722 (1977-09-01), Rowland
Nature, vol. 255 pp. 487-488 (1975).
Lancet, pp. 1105-1106 (1977).
Proc. Natl. Acad. Sci., U.S.A. vol. 79, pp. 621-625 (1982).

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