Clottable fibrinogen free Factor VIII product and process

Details Clottable fibrinogen free Factor VIII product and process Clottable fibrinogen free Factor VIII product and process

1976-12-15

1978-04-18

Danison, Walter C.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

424101, A23J 106, A61K 3514

Patent

active

040850951

ABSTRACT:
Lyophilizable, clottable fibrinogen free, Factor VIII is produced on a commercial scale from a fibrinogen containing Factor VIII concentrate by sequentially, precipitating a major portion of the clottable fibrinogen by the addition of an ethylene oxide-polyoxypropylene block copolymer, clotting the remainder of the clottable fibrinogen by the addition of a small amount of a thrombin mimetic enzyme which does not decrease the potency of the Factor VIII, and adding human albumin to the resultant clottable fibrinogen free Factor VIII to stabilize its potency during lyophilization.

REFERENCES:
patent: 3973002 (1976-08-01), Hagan et al.
patent: 4022758 (1977-05-01), Andersson et al.
Kevy, Chemical Abstracts, vol. 78: 69,608g, (1973).

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