Synthetic polypeptides as inhibitors of HIV-1

Details Synthetic polypeptides as inhibitors of HIV-1 Synthetic polypeptides as inhibitors of HIV-1

1992-03-26

1995-08-22

Warden, Jill

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

530300, 530324, 530350, A61K 3800, C07K 500, C07K 700, C07K 1700

Patent

active

054440440

ABSTRACT:
A synthetic HIV-1-based polypeptide as well as methods for topically inhibiting HIV-1 infectivity or replication. The polypeptide of the present invention has an amino acid sequence substantially corresponding to a specified region of the HIV-1.sub.IIIB virus. The polypeptide of the present invention may be administered in effective amounts for topically inhibiting HIV-1 infectivity or replication. The polypeptide is useful for inhibiting the replication of the HIV-1 virus as well as HIV-1-mediated cytopathogenesis and cell fusion at levels which are within acceptable ranges of cytotoxicity.

REFERENCES:
Ratner, et al., "Complete Nucleotide Sequence of the AIDS Virus", Nature, vol. 313, pp. 277-284, (Jan. 24, 1985).
Neurath, et al., "B Cell Epitope Mapping of Human Immunodeficiency Virus Envelope Glycoproteins with Long (19- to 36-) Synthetic Peptides", Journal of General Virology, 71, pp. 85-95 (1990).
Neurath et al., Virology, vol. 188, pp. 1-13, 1992.

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