Method of producing .alpha.-hydroxyisobutyramide from acetone cy

Details Method of producing .alpha.-hydroxyisobutyramide from acetone cy Method of producing .alpha.-hydroxyisobutyramide from acetone cy

1992-08-19

1995-08-22

Marx, Irene

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing nitrogen-containing organic compound

435227, C12P 1302, C12N 978

Patent

active

054439736

ABSTRACT:
A culture liquid of microorganisms having an ability of producing .alpha.-hydroxyisobutylamide from acetone cyanhydrin or the cultivated cells of the microorganisms or the processed cells of them is/are reacted to acetone cyanhydrin in an aqueous medium to produce .alpha.-hydroxyisobutylamide. The amide is reacted with water and/or an aliphatic alcohol in the presence of a solid acid catalyst at a temperature of 150.degree. C. or higher in a gaseous phase or a gaseous-liquid mixed phase to produce an .alpha.,.beta.-unsaturated carboxylate or an aliphatic alcohol or an .alpha.,.beta.-unsaturated carboxylic acid.

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patent: 5200331 (1993-04-01), Kawakami
Klibanov, A., "Enzymes that work in Organic Solvents", Chemtech, pp. 354-359, 1986.
Klibanov, A., "Enzymelic Catalysis in Anhydrous Organic Solvents", TIBS Apr. 1989.
Zaks, A. et al, "Enzyme-catalyzed Processes in Organic Solvent", vol. 82 pp. 3192-3196, 1985.
"Substrates and Inhibitors of the Nitrile Hydratase and Amidase of Corynebacterium nitrilophilus", T. Amarant et al, Biotech. & Applied Bichem. vol. 11, pp. 49-59 (1989).

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