Imidazolyl-alkenoic acids useful as angiotensin II receptor anta

Details Imidazolyl-alkenoic acids useful as angiotensin II receptor anta Imidazolyl-alkenoic acids useful as angiotensin II receptor anta

1993-06-14

1995-05-23

Higel, Floyd D.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514341, 5483151, A61K 31415, C07D23366, C07D40906

Patent

active

054182506

ABSTRACT:
Angiotensin II receptor antagonists having the formula: ##STR1## which are useful in regulating hypertension and in the treatment of congestive heart failure, renal failure, and glaucoma, pharmaceutical compositions including these antagonists, and methods of using these compounds to produce angiotensin II receptor antagonism in mammals.

REFERENCES:
patent: 4340598 (1982-07-01), Furukawa et al.
patent: 4355040 (1982-10-01), Furukawa et al.
patent: 5185351 (1993-02-01), Finrelstein et al.
Berger, "Medicinal Chemistry", 2nd Ed., pp. 565-571, 600, 601 (1960).
Denrewalter et al, "Progress in Drug Research", vol. 10, pp. 510-512 (1966).

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