Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Patent
1993-02-10
1995-05-23
Scheiner, Toni R.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
435960, 436518, 436172, 436811, 436536, G01N 33537, G01N 3368, G01N 33543
Patent
active
054181399
ABSTRACT:
Disclosed herein are methods for screening for primary cardiomyopathy. The methods are preferably immunological methods in which the level of binding of a monoclonal or polyclonal antibody to a 50 kD glycoprotein component of a mammalian muscle tissue is determined. This level of binding is compared to the level of binding observed when non-dystrophic tissue is treated in an otherwise identical manner. A substantial reduction in the level of binding to the 50 kD glycoprotein in the experimental mammalian muscle tissue has been determined to be a screen for primary cardiomyopathy.
REFERENCES:
patent: 5187063 (1993-02-01), Campbell
Geisterfer-Lowrance, et al., "A Molecular Basis for Familial Hypertrophic Cardiomyopathy: A .beta. Cardiac Myosin Heavy Chain Gene Missense Mutation", Cell 62:999-1006, (1990).
Nigro, et al., "The Incidence and Evolution of Cardiomyopathy in Duchenne Muscular Dystrophy", International Journal of Cardiology 26:271-277, (1990).
Anan, et al., "Myocardial Patchy Staining of Dystrophin in Becker's Muscular Dystrophy Associated With Cardiomyopathy", American Heart Journal 123:1088-1089 (1992).
Roberds, S. L. et al J. Biol. Chem. 268(16):11496 Jun. 5 1993.
Byers, T. J. et al J. Cell Biol. 115(2):411 Oct. 1991.
Valetine, B. A. et al Am. J. Pathol. 135(4):671 Oct. 1989.
Farrell Kevin M.
Parsons Nancy J.
Scheiner Toni R.
University of Iowa Research Foundation
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