Prolonged release bioadhesive vaginal gel dosage form

Details Prolonged release bioadhesive vaginal gel dosage form Prolonged release bioadhesive vaginal gel dosage form

1999-02-12

2000-12-12

Azpuru, Carlos A.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Implant or insert

424434, A61F 606, A61F 1302

Patent

active

061594911

ABSTRACT:
The present invention relates to a bioadhesive, prolonged release vaginal gel dosage form comprising a synergistic formulation of carrageenan, acrylic acid containing polymers, agarose and an effective amount of a therapeutic agent, whereby the therapeutic agent is released from this composition initially at a first relatively high rate, to provide a loading dose of the therapeutic agent, followed by a second, lower rate of release that provides a constant, maintenance dose of the therapeutic agent for up to 24 hours. More specifically, the present invention includes compositions within which the agarose is ultra low gelling temperature agarose and the acrylic acid containing polymer may be carbophil, a copolymer of acrylic acid and divinyl alcohol, a copolymer of acrylic acid and C.sub.10 to C.sub.30 alkyl acrylic acid or a polyacrylic acid homopolymer.

REFERENCES:
patent: 3865108 (1975-02-01), Hartop
patent: 4226848 (1980-10-01), Nagai et al.
patent: 4250163 (1981-02-01), Nagai et al.
patent: 4615697 (1986-10-01), Robinson
patent: 4707362 (1987-11-01), Nuwayser
patent: 4708834 (1987-11-01), Cohen et al.
patent: 4755378 (1988-07-01), Buxton et al.
patent: 4795436 (1989-01-01), Robinson
patent: 4983392 (1991-01-01), Robinson
patent: 4983393 (1991-01-01), Cohen et al.
patent: 5008117 (1991-04-01), Calanchi et al.
patent: 5069906 (1991-12-01), Cohen et al.
patent: 5225196 (1993-07-01), Robinson
patent: 5330761 (1994-07-01), Baichwal
patent: 5455046 (1995-10-01), Baichwal
patent: 5472704 (1995-12-01), Santus et al.
patent: 5474768 (1995-12-01), Robinson
patent: 5478574 (1995-12-01), Baichwal et al..
patent: 5587175 (1996-12-01), Viegas et al.
patent: 5624675 (1997-04-01), Kelly
patent: 5650192 (1997-07-01), Britton et al.
patent: 5667492 (1997-09-01), Bologna et al.
patent: 5672356 (1997-09-01), Rault et al.
patent: 5700486 (1997-12-01), Canal et al.
patent: 5714159 (1998-02-01), Shalaby
patent: 5759520 (1998-06-01), Sachetto
patent: 5783212 (1998-07-01), Fassihi et al.
patent: 5817343 (1998-10-01), Burke
patent: 5824343 (1998-10-01), Ng et al.

Affiliated with

Also associated with

Rating

Prolonged release bioadhesive vaginal gel dosage form does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Prolonged release bioadhesive vaginal gel dosage form, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Prolonged release bioadhesive vaginal gel dosage form will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-213828