Process for preparing .alpha.-amino acid amides, .alpha.-amino a

Details Process for preparing .alpha.-amino acid amides, .alpha.-amino a Process for preparing .alpha.-amino acid amides, .alpha.-amino a

1997-11-20

1999-11-02

Reamer, James H.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acids and salts thereof

548230, C07C22718, C07D26320

Patent

active

059774061

ABSTRACT:
The invention relates to a process for preparing .alpha.-amino acid amides, the corresponding .alpha.-amino acids, or salt thereof, which are substituted at the .beta.-site with at least one (hetero)aromatic group. This is achieved according to the invention by subjecting a 4-carbamoyl-2-oxazolidinone compound, respectively a 4-carboxy-2-oxazolidinone compound, wherein each of them is substituted at the 5-site with at least one (hetero)aromatic group, to a treatment with H.sub.2 in the presence of a catalyst. The invention also relates to a process for preparing a 4-carbamoyl-2-oxazolidinone compound substituted at the 5-site with at least one (hetero)aromatic group, in which process an .alpha.-amino-.beta.-hydroxy-propane nitrile substituted at the .beta.-site with at least one (hetero)aromatic group, or a salt thereof, is subjected to a treatment in the presence of CO.sub.2 and a base.

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Shuji et al., Nuclear Magnetic, Resonance Study of the Stereoisomeric 2-oxazolidinone and 2-phenyl-2-oxazoline Derivatives of .alpha.-amino-.beta.-hydroxy Acids, Bulletin of the Chemical Society of Japan, vol. 46, No. 10, pp. 3308-3310 (1973).

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