Process for preparing N-[1- (S)-ethoxycarbonyl-3- phenylpropyl]-

Details Process for preparing N-[1- (S)-ethoxycarbonyl-3- phenylpropyl]- Process for preparing N-[1- (S)-ethoxycarbonyl-3- phenylpropyl]-

1999-02-17

1999-11-02

Powers, Fiona T.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

546133, 546183, 548136, 5483225, 548409, 560 39, C07D20712, C07D23326, C07D21716, C07D49510

Patent

active

059773804

ABSTRACT:
A process for synthesizing N-[1-(S)-ethoxycarbonyl-3-phenylpropyl]-L-alanine derivatives of the following formula (I): ##STR1## in which the definition of R has the same meaning as given in the description by using a sulfite derivative to activate the C-terminus of the three dimensional structure of an amino acid of N-[1-(S)-ethoxycarbonyl-3- phenylpropyl]-L-alanine, which can effectively couple with another amino acid to form a dipeptide of formula (I). The compound of fomula (I) is an inhibitor of ACE.

REFERENCES:
patent: 4716235 (1987-12-01), Takahashi et al.
patent: 5359086 (1994-10-01), Merslavic et al.
patent: 5686627 (1997-11-01), Murthy et al.
patent: 5869671 (1999-02-01), Wang et al.
Yamazaki et al., Tetrahedron, 1974, 30(11), 1319-1321.

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