Probes and detection method for a human interferon-inducible pro

Details Probes and detection method for a human interferon-inducible pro Probes and detection method for a human interferon-inducible pro

1997-11-07

1999-11-02

Ulm, John

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 235, 536 2431, 435 691, C12N 1511, C12N 1512, C12N 1519

Patent

active

059773383

ABSTRACT:
The present invention provides a novel human interferon-inducible protein (HIFI) and the polynucleotides which identify and encode HIFI. The invention provides for genetically engineered expression vectors and host cells comprising the nucleic acid sequence encoding HIFI and for a method for producing the protein. The invention also provides pharmaceutical compositions containing HIFI and the use of such compositions for the prevention or treatment of diseases associated with the expression of HIFI. Additionally, the invention provides antisense molecules to HIFI and their use in the treatment of diseases associated with the expression of HIFI. The invention also provides diagnostic assays which utilize polynucleotides which hybridize with naturally occurring sequences encoding HIFI and antibodies which specifically bind to the protein.

REFERENCES:
Genexpress, Direct Submission Oct. 24, 1994 to Genethon, Locus HSC1ZCO32, Accession#Z40315.
Hardman, J.G., et al., "The Pharmacological Basis of Therapeutics", pp. 1211-1215 (1966).
Kato, T., et al., "Interferon-Inducible Gene Expression in Chimpanzee Liver Infected with Hepatitis C Virus", Virology, 190:856-860 (1992).
Kelly, J.M., et al., "Characterization of a human gene inducible by .alpha.- and .beta.- interferons and its expression in mouse cells", EMBO J, 5:1601-1606 (1986).
Rasmussen, U.B., et al., "Indentification of a New Interferon-.alpha.-inducible Gene (p27) on Human Chromosome 14q32 and Its Expression in Breast Carcinoma", Cancer Res., 53:4096-4101 (1993).

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