Process for preparing certain decahydro-7H-3-ol-7-ones

Details Process for preparing certain decahydro-7H-3-ol-7-ones Process for preparing certain decahydro-7H-3-ol-7-ones

1988-07-25

1990-05-22

Rotman, Alan L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Oxygen containing

560256, 546318, C07C 49403, C07C 49497, C07C 49603

Patent

active

049279750

ABSTRACT:
Novel antiandrogenic compositions comprising an antiandrogenically effective amount of at least one compound of the formula ##STR1## wherein R is alkyl of 1 to 4 carbon atoms, R.sub.1 is alkyl of 1 to 2 carbon atoms, R.sub.2 is selected from the group consisting of hydrogen, alkyl of 1 to 8 carbon atoms optionally interrupted with a heteroatom, alkenyl and alkynyl of 2 to 8 carbon atoms optionally interrupted with a heteroatom, formyl and acyl of an organic carboxylic acid of 2 to 18 carbon atoms, R.sub.3 is selected from the group consisting of hydrogen, alkyl of 1 to 4 carbon atoms and alkenyl and alkynyl of 2 to 4 carbon atoms, R.sub.4 is selected from the group consisting of hydrogen and alkyl of 1 to 4 carbon atoms, the dotted lines indicate optional presence of a double bond between the 4(5) and 5a(6) carbons and the wavy line indicates that R.sub.4 may be in the .alpha.- or .beta.-position and a non-toxic, pharmaceutical carrier or excipient and a method of treating hyperandrogenic conditions in warm-blooded animals.

REFERENCES:
patent: 3496199 (1970-02-01), Uskokovic
patent: 3499912 (1970-03-01), Uskokovic et al.
patent: 3956316 (1976-05-01), Uskokovic et al.

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