Antiproliferative protein from Bacillus thuringiensis var. thuri

Details Antiproliferative protein from Bacillus thuringiensis var. thuri Antiproliferative protein from Bacillus thuringiensis var. thuri

1997-04-02

1999-11-02

Hendricks, Keith D.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 12, 530350, C07K 1432

Patent

active

059770589

ABSTRACT:
The present invention provides an isolated and purified protein derived from Bacillus thuringiensis subspecies thuringiensis, having a molecular weight of approximately 20 kDa of SDS-PAGE, said protein having the partial amino acid sequence shown in SEQ ID No. 1, and wherein said protein displays cytotoxic effects against tumor cells. Also provided is a method of treating a neoplastic cell comprising administering a therapeutically effective dose of the composition of the present invention to said cell, and a method of activating macrophages, comprising administering a therapeutically effective dose of the composition of the present invention to said macrophages.

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