Condensed seven-membered ring compounds, their production and us

Details Condensed seven-membered ring compounds, their production and us Condensed seven-membered ring compounds, their production and us

1985-01-14

1987-01-20

Bond, Robert T.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

546227, 546245, 560 51, 560 53, 560174, 560177, 560226, 560150, 560 10, 540491, A61K 3155, C07D41712

Patent

active

046380000

ABSTRACT:
Novel condensed seven-membered ring compounds of the formula: ##STR1## [wherein R.sup.1 and R.sup.2 are independently hydrogen, halogen, trifluoromethyl, lower alkyl or lower alkoxy, or both jointly form tri- or tetramethylene; R.sup.3 and R.sup.5 are independently hydrogen, lower alkyl or aralkyl; R.sup.4 is hydrogen or lower alkyl; R.sup.6 is a condensed or non-condensed hetero-alicyclic containing at least one atom of N, O and S as a ring-forming atom which may be substituted; A is an alkylene chain; n is 1 or 2] and salts thereof.
These compounds exhibit inhibitory activity on angiotensin converting enzyme and so forth, and are of value as an agent for diagnosis, prevention and treatment of circulatory diseases, such as hypertension, cardiopathy and cerebral apoploxy.

REFERENCES:
patent: 3341519 (1967-09-01), Krapcho
patent: 4460579 (1984-07-01), Karanewsky
patent: 4477464 (1984-10-01), Slade et al.
patent: 4539150 (1985-09-01), Katakami et al.
Chemical Abstracts vol. 94, p. 657 (1981), Registry No. 94: 156884t.
Central Patents Index, Basic Abstracts Journal, Section B: FARMDOC, 01015 E/01 B02 TANA 02.05.80 J56156-218 (Mar. 3, 1982).
Central Patents Index, Basic Abstracts Journal, Section B: FARMDOC, 82663 E/39 B02 NIPK 18.02.81 J57136-581 (Nov. 24, 1982).
Central Patents Index, Basic Abstracts Journal, Section B: FARMDOC, 01471 J/47 B02 HAMA 3.04.81 J57169-474 (Jan. 26, 1983).

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