Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1995-12-21
1997-05-06
Haley, Jacqueline
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514321, 546192, 548428, A61K 3140, C07D51314
Patent
active
056272030
ABSTRACT:
The present invention relates to compounds of formula (I): ##STR1## wherein A, x, y, R.sub.1, R.sub.2 and R.sub.3 are as defined in the description. The compounds are useful for treating diseases requiring a selective serotonin reuptake site and 5-HT.sub.2c or 5-HT.sub.3 ligand.
REFERENCES:
patent: 3903164 (1975-09-01), Goransson-Dahlander
patent: 4308399 (1981-12-01), Takacs et al.
patent: 4395413 (1983-07-01), Budai et al.
Kilpatrick, Gavin J., et al., 5-HT.sub.3 Receptors, Medicinal Research Reviews, vol. 10, No. 4, 441-475 (1990).
Hoyer, Danies, et al., VII. International Union of Pharmacology Classification of Receptors for 5-Hydroxytryptamine (Serotonin), Pharmacology Reviews, vol. 46, No. 2, 157-203 (1994).
Langer, S.Z., et al., Inhibitors of Serotonin Uptake, in Serotonin from Cell Biology to Pharmacology and Therapeutics, (P.M. Vanhoutte, et al. eds.) 197-205 (1993 Kluwer Academic Publishers).
Guardiola-Lemaitre B eatrice
Lancelot Jean-Charles
Pfeiffer Bruno
Prunier Herv e
Rault Sylvain
Adir et Compagnie
Haley Jacqueline
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