Adhesion receptor antagonists

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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514252, 514316, 544364, 544369, 544370, 546187, 546209, A61K 31445, C07D21148

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active

056271972

ABSTRACT:
Compounds of the formula I ##STR1## wherein R.sup.1 and Y have the meanings indicated herein, and also their physiologically acceptable salts, inhibit the binding of fibrinogen to the corresponding receptor and can be employed for the treatment of thromboses, osteoporoses, oncoses, apoplexy, cardiac infarct, inflammations, arteriosclerosis and osteolytic disorders.

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Nierodzick, M. L. et al. Thrombosis and Haemostasis, 1995 (Jul), 74(1), pp. 282-290.
Valentin-Weigand et al., Infection and Immunity, 56(11):2851-2855 (Nov. 1988) Born, Nature, 194(4832):927-929 (Jun. 9, 1962).

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