Oxazole and oxadiazole cephalosporins

Details Oxazole and oxadiazole cephalosporins Oxazole and oxadiazole cephalosporins

1982-01-19

1983-09-27

Rizzo, Nicholas S.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

544 25, 544 24, 544 27, C07D50138, A61K 31545

Patent

active

044068980

ABSTRACT:
Broad spectrum cephalosporin antibiotics represented by the betaine structure of the formula ##STR1## wherein R is a 5-membered amino-substituted heterocyclic containing oxygen and nitrogen; R' is e.g., hydrogen or C.sub.1 -C.sub.4 alkyl; and bicyclicpyridinium is a thienopyridinium or a furopyridinium group; are prepared by reacting a silylated 3-iodomethyl cephalosporin with a thienopyridine, e.g., thieno[2,3-b]pyridine or a furopyridine. The compounds are potent antibacterials against gram-positive and gram-negative organisms. Pharmaceutical compositions and a method for treating bacterial infections are also provided.

REFERENCES:
patent: 4258041 (1981-03-01), O'Callaghan et al.
patent: 4264595 (1981-04-01), Numaoa et al.
patent: 4278671 (1981-02-01), Ochiai et al.
patent: 4278793 (1981-07-01), Durckheimer et al.

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