Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Virus or component thereof
Patent
1981-06-25
1983-09-27
Friedman, Stanley J.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Virus or component thereof
424230, 424246, 424270, A61K 3143, A61K 3154, A61K 31425, A61K 31625
Patent
active
044068964
ABSTRACT:
A method and drug form for enhancing the rate of absorption of a rectally administered drug from the rectal compartment into the blood stream of a warm blooded animal. The method includes the steps of preparing a .beta.-lactam drug form capable of being rectally administered. The drug form comprises a therapeutically effective unit dosage amount of a selected drug of the type which is capable of being absorbed into the blood stream from the rectal compartment and hydroxy aryl or hydroxy aralkyl acids or salts, amides or esters thereof, the hydroxy aryl or hydroxy aralkyl acids or salts, amides or esters thereof being present in the drug form in a sufficient amount to be effective in enhancing the drug absorption rate, when rectally administering the drug form to warm blooded animals.
REFERENCES:
Chemical Abstracts, 83, 205953y (1975) Toyoshima et al., Insulin Complex Salts with Aminobenzoate Derivatives.
Chemical Abstracts, 71, 89823g (1969) Sugimoto, Isao, Complexes XVI-Effect of Complex Formation on Drug Absorption etc.
Pharmaceutical Res. Laboratory, Yakugaku Zasshi, 88(5)618-622, Studies on Complexes-Effect of Complex Formation on Drug Absorp. etc.
CA 69-65889 (17)-Complexes-Effect of Complex Formation on Drug Absorption from Alimentary Tract, Susimoto, Isao et al., Tanabe Seiyaku Co. Ltd., Osaka, Yakusaku Zasshi V88F(6) pp. 690-694 (1968).
CA 69-50670 (13), Complexes, Effect of Complex Formation Drug Absorption from Alimentary Tract, Susimoto, Issao, Tababe Seiyaku Co., Ltd., Japan Pharm. Bull. 16(6), pp. 1098-1104 (1968).
CA 69-94857(23) Complexes, Effect of Complex Formation on Drug Absorption from Alimentary Tract, Susimoto, Isao, Tanabe Seiyaku Co., Ltd., Pharm. Res. Chem. Bull. 16(8) pp. 1527-1532 (1968).
CA 71-33382(8) Complexes, Effect of Complex Formation on Drug Absorption from Alimentary Tract, Susimoto, Isao Tanabe Seiyaku Co. Ltd., Pharm. Res. Chem. Pharm. Bull. 17(5) pp. 994-998 (1969).
Shunji Ota Dept. Pharmacol. Showa Med. Col. Comments: Jap. 5 Pharm. 51 pp. 692-714 (1955) Influence of Various Substances on the Absorption of Histamine from the Large Intestine etc.
Microbiologic Pharmacologic Properties of New Ampicillin Deriv. etc. by Valcavi, R. Caponi et al.
Journal of Pharmaceutical Sciences, vol. 57, No. 8 (1968) Reuning et al., Effect of Complex Formation on Drug Absorption etc., pp. 1335-1341.
Journal American Pharm. Assoc. No. 9, pp. 527-530, Investigation of Complex Formed in Solution by Caffeine, Higuchi et al.
Higuchi Takeru
Nishihata Toshiaki
Rytting Howard J.
Friedman Stanley J.
Merck & Co. , Inc.
Monaco M. A.
Riedl E. D.
Sudol, Jr. M. C.
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