Finasteride processes

Details Finasteride processes Finasteride processes

1997-03-26

1999-03-23

Rotman, Alan L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

514284, C07D22118, A61K 31435

Patent

active

058861840

ABSTRACT:
Disclosed is a new process for producing finasteride which involves reacting the magnesium halide salt of 17.beta.-carboalkoxy-4-aza-5.alpha.-androst-1-en-3-one with t-butylamino magnesium halide, present in at least a 2:1 molar ratio to the ester, formed from t-butyl amine and an aliphatic/aryl magnesium halide at ambient temperature in an inert organic solvent under an inert atmosphere followed by heating and recovering the product finasteride.
Also disclosed are two polymorphic crystalline Forms I and II of finasteride, and methods of their production.

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