Sun protection preparation with an increased sun protection fact

Details Sun protection preparation with an increased sun protection fact Sun protection preparation with an increased sun protection fact

1997-05-06

1999-03-23

Dodson, Shelley A.

Drug, bio-affecting and body treating compositions

Topical sun or radiation screening, or tanning preparations

424 60, 424400, 424401, A61K 742, A61K 744, A61K 700

Patent

active

058855580

DESCRIPTION:

BRIEF SUMMARY
This invention relates to a sun protection preparation with an increased sun protection factor.
Numerous sun protection preparations have become known. Topical sun protection preparations, as a rule, can either be categorized as chemical or physical sun protection preparations. The chemical sun protection preparations that are of interest here contain one or several UV-absorbing substances and, after a thin and invisible film of such preparation has been applied to the skin, act as a screen preventing ultraviolet radiation from penetrating to the living cells of the epidermis. Chemical sun protection preparations are usually colourless as they do not contain any substances that absorb visible light, and they are therefore cosmetically acceptable for most people provided that they do not irritate the eyes, are non-photosensitizing, stable and non-volatile, and that they do not leave any stains on people's skin and clothing. Most commercial sun protection preparations contain one or several chemicals which absorb UV-B radiation, and furthermore they contain a moisturizing base. A more recent ingredient of known sun protection preparations have been UV-A radiation-absorbing substances, mostly various benzophenones. Most chemical sun protection preparations used comprise p-aminobenzoic acid (PABA), PABA esters (amyl dimethyl PABA and octyl dimethyl PABA), benzophenones, cinnamates (octyl methoxycinnamate and cinnoxate), salicylates (homomenthyl salicylate), and anthranilates.
Sun protection preparations that contain a-hydroxy acids or their derivatives have been known from WO 94/06409 (PCT/US92/11037) by Perricone et al. Furthermore, sun protection preparations have been known from WO93/19729 (PCT/US93/02712) that contain a combination of retinoic acid and various derivatives thereof with pharmaceuticals.
WO93/11742 (PCT/EP92/02897) proposes a portion of 0.5 to 30 wt % of titanium dioxide and/or zinc oxide, or 0.001 to 2 wt % of iron oxide, the mean primary particle size of said iron oxide being about 200 nm. These particles may also be coated with phospholipids.
It has become a generally accepted practice to specify the sun protection factor (SPF) of sun protection preparations. There is a great interest in increasing said sun protection factor so that the product can be used by many people and invariably causes a pleasant dermal sensation. The medium-range sun protection factors from SFP 10 to 20 are of particular interest in this respect.
It is therefore the object of the invention to provide novel sun protection preparations having an improved sun protection factor.
A sun protection preparation according to the invention consists of ranging from 1 to 10 .mu.m; (B) ranges from 3 to 12 wt %, relative to the total composition.
A particularly advantageous preparation contains the component (A) with a mean particle size of 4.5 .mu.m.
In another preferred embodiment, the ratio of (A) to (B) ranges from 1:2.5 to 8, preferably from 1:3 to 5.
In yet another preferred embodiment, the total portion of components (A) and (B) is 4 to 8 wt %, relative to the total composition.
The fine-particle, crosslinked poly(methylsiloxane) which constitutes component (A) is a product that specifically has the following properties: 900.degree. C.; up to about 350.degree. C. and is reduced by 25% or less at 900.degree. C. While retaining its generally circular structure; 10.degree. C. per minute; aromates, and chlorinated hydrocarbons.
A particularly advantageous poly(methylsiloxane) is the commercial product named Tospearl.RTM., in particular Tospearl 145.RTM. by Toshiba Silicone Co., Ltd., available from Kobo Products, Inc., N.J., U.S.A.
It is known that component (B), octyldodecyl neopentanoate (CTFA name), is an emollient. A particularly advantageous commercial product is Elefac I 205.RTM. (available from Bermel Chem. Comp., Englewood, N.J., U.S.A.). When this component (B) is used in a preparation with UV screens and other common adjuvants and additives, a sun protection factor of about 16 is obtained.
Surprisingly, the sun prot

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