Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1987-02-26
1989-12-12
Moskowitz, Margaret
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
514 13, 514895, 530326, 530324, 424 88, 424 89, A61K 3912, C07K 708, C07K 710
Patent
active
048867829
ABSTRACT:
The circumsporozoite (CS) protein of Plasmodium falciparum has been analyzed to develop a new anti-sporozoite malarial vaccine. Localization of sites for T-cell recognition on this molecule is critical for vaccine design. By using an algorithm designed to predict T-cell sites and a large panel of H-2 congenic mice, a major nonrepetitive T-cell was located. When a synthetic peptide corresponding to this site was covalently linked to the major B-cell site on the molecule, an immunogen capable of eliciting a high titer antibody response was formed. This peptide sequence is capable of priming helper T-cells for a secondary response to the intact CS protein. This site represents the first helper T-cell site described for the CS molecule outside of the repetitive region, and is a major immunodominant T-site on the molecule. The approach described herein is useful in the rational design and construction of more efficacious vaccines.
REFERENCES:
Gibson et al., Proc. Nat'l. Acad., Sci. USA 83, 5649-5653(1986).
Good et al., J. Exper. Med. 164:655-660 "Genetic Control of the Immune Response in Mice to a Plasmodium falciparum Sporozoite Vaccine", 1986.
Dame et al., Science 225:593-599, "Structure of the Gene Encoding the Immunodominant Surface Antigen on the Sporozoite . . .", 1984.
Miller et al., Science 234:1349-1356, "Research Toward Malaria Vaccines", 1986.
Chen et al., J. of Immun. 118:1322-1327, "Immunity to Sporozoite-Induced Malaria Infection in Mice", 1977.
Mazier et al., Science 213:156-159, "Effect of Antibodies to Recombinant and Synthetic Peptides on P. falciparum Sporozoites in Vitro", 1986.
Berzofsky Jay
Good Michael A.
Miller Louis H.
Jain Mishrilal
Moezie F. T.
Moskowitz Margaret
The United States of America as represented by the Department of
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