Polyanion-stabilized aluminum hydrogels

Drug – bio-affecting and body treating compositions – Conjugate or complex of monoclonal or polyclonal antibody,... – Conjugated via claimed linking group – bond – chelating agent,...

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424 78, 424 79, 424154, 424157, 424158, 424177, A61K 31715, A61K 31725, A61K 3306

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active

041817184

ABSTRACT:
Aluminum hydrogels which are stabilized at pH below 7 with a polymer containingcarboxyl groups, e.g., carboxy methyl cellulose or gum arabic. The gels are useful as phosphate binding agents in the treatment of hyperphosphatemia. Such polymers are incorporated during the formation of the aluminum hydrogel, permitting a high yield to be obtained, and preventing colloidal sol formation during exchange with monovalent anions.

REFERENCES:
patent: 3175942 (1965-03-01), Anderson et al.
patent: 3326755 (1967-06-01), Sheth
patent: 3364111 (1968-01-01), Morii et al.
patent: 3555151 (1971-01-01), Kaplan et al.
patent: 3579634 (1971-05-01), Brown

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