Antibacterial 3-(5-tetrazolyl) penam compounds

Details Antibacterial 3-(5-tetrazolyl) penam compounds Antibacterial 3-(5-tetrazolyl) penam compounds

1977-04-12

1978-09-19

Schwartz, Gerald A.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

2603067R, 424270, 424271, C07D49928

Patent

active

041153855

ABSTRACT:
Certain novel 6-acylamino-2,2-dimethyl-3-(5-tetrazolyl)penam derivatives, and salts thereof; their use as broad-spectrum antibacterial agents; and methods for their preparation. Their preparation comprises acylation of the novel intermediate, 6-amino-2,2-dimethyl-3-(5-tetrazolyl)penam or simple derivatives thereof, followed, in some cases, by further transformations of the 6-acylamino group or by removal of a protecting group from the 5-tetrazolyl moiety. Process for the preparation of 6-amino-2,2-dimethyl-3-(5-tetrazolyl)penam, simple derivatives thereof and intermediates therefor.

REFERENCES:
patent: 3316273 (1967-04-01), Gottstein et al.
patent: 3427302 (1969-02-01), Essery
patent: 3468874 (1969-09-01), Raap et al.
Gottstein et al., J. Org. Chem., 31, 1922 (1966).

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