Novel glycopeptide derivatives

Details Novel glycopeptide derivatives Novel glycopeptide derivatives

1986-04-18

1987-10-06

Phillips, Delbert R.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

530317, 530322, A61K 3566, A61K 3702, C07K 750, C07K 900

Patent

active

046983279

ABSTRACT:
Novel glycopeptide antibiotics of formula (I) can be prepared from the glycopeptide antibiotics vancomycin, A51568A, A51568B, M43A and M43D by reaction with a ketone or aldehyde followed, if appropriate, by reduction. The new glycopeptide derivatives are useful antibacterial agents.

REFERENCES:
patent: 3067099 (1962-12-01), McCormick et al.
patent: 4495179 (1985-01-01), Hoehn et al.
patent: 4547488 (1985-10-01), Merkel
patent: 4548925 (1985-10-01), Higgins, Jr. et al.
patent: 4558008 (1985-12-01), Boeck et al.
Harris et al., "Structure of the Glycopeptide Antibiotic Vancomycin, Evidence for an Asparagine Residue in the Piptide," J. Am. Chem. Soc., 104, 4293-4295 (1982).
Pfeiffer, "Structural Features of Vancomycin," Reviews of Infectious Diseases, vol. 3, Suppl., S205-S209 (Nov.-Dec. 1981).

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