Substituted-5-methylidene hydantoins with AT.sub.1 receptor anta

Details Substituted-5-methylidene hydantoins with AT.sub.1 receptor anta Substituted-5-methylidene hydantoins with AT.sub.1 receptor anta

1992-11-19

1994-05-03

Higel, Floyd D.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514341, 514365, 514374, 514378, 514381, 514397, 546246, 548189, 548240, 548253, 5483144, A61K 31415, A61K 3144, C07D23372, C07D23384, C07D40106

Patent

active

053088530

ABSTRACT:
Substituted 1-benzylimidazole-5-methylidene hydantoins are disclosed as well as methods of preparing them, pharmaceutical compositions containing them, and method of using them. Intermediates useful in the preparation of the compounds of the invention are also disclosed and synthetic methods for preparing the novel intermediates. The compounds are useful as antagonists of angiotensin II and thus are useful in the control of hypertension, hyperaldosteronism, congestive heart failure, surgically induced vascular smooth muscle proliferation, and glaucoma.

REFERENCES:
patent: 3122583 (1964-02-01), Galloway
patent: 3852056 (1974-12-01), Draber et al.
patent: 4335040 (1982-10-01), Furukawa
patent: 4810800 (1989-03-01), Matthews et al.
patent: 4820843 (1989-04-01), Aldrich
patent: 5177097 (1993-01-01), Poss
patent: 5185351 (1993-02-01), Finkelstein et al.
Kauffman et al, Life Sciences, vol. 49(25), pp. 223-228 (1991).
Meanwell et al, J. Org. Chem., vol. 56, pp. 6897-6904 (1991).

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