Production of the E. coli LT-B enterotoxin subunit

Details Production of the E. coli LT-B enterotoxin subunit Production of the E. coli LT-B enterotoxin subunit

1993-02-17

1994-05-03

Low, Christopher S. F.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 2, 530350, 530806, 530403, 424 88, 424 92, 424 65, 424 73, 935 10, 935 12, 435 71, 4353201, 4351723, 435 693, 930200, A61K 39108, A61K 3902, C07K 1504

Patent

active

053088352

ABSTRACT:
Methods and compositions are provided for the cloning and expression of genes coding for the non-toxic subunit of the heat-labile enterotoxin (LT-B) of E. coli. The LT-B thus produced may be formulated for use as an immunogen in vaccines. Specific antibodies produced by this invention may be used in diagnostic tests for the detection of Vibrio cholerae or LT positive enterotoxigenic E. coli. The antibodies of this invention may further be formulated into passive vaccines for the prophylactic or therapeutic protection of human beings or other mammalian species against diarrheal diseases caused by Vibrio cholerae or by the LT positive enterotoxigenic E. coli or other bacteria.

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