Peptides having somatostatin activity

Details Peptides having somatostatin activity Peptides having somatostatin activity

1979-03-13

1980-02-26

Phillips, Delbert R.

Drug, bio-affecting and body treating compositions

Immunoglobulin, antiserum, antibody, or antibody fragment,...

Reduced antigenicity, reduced ability to bind complement, or...

2601125S, A61K 37100, C07C10352

Patent

active

041906489

ABSTRACT:
Peptides having the structural formula: ##STR1## wherein A is D-Thr, D-Val;
B is D-Phe, D-Tyr;
C is D-Phe, D-Tyr, O-Me-D-Tyr;
wherein the ring formed by the peptide backbone contains 26 atoms and pharmaceutically acceptable non-toxic acid addition salts thereof are prepared by the solid phase method. These peptides have the property of inhibiting release of insulin, inhibiting growth hormone release and inhibiting glucagon release in humans and animals without materially affecting gastric secretion. They have a longer duration of action than somatostatin.

REFERENCES:
patent: 4146612 (1979-03-01), Veber
Immer, H., Proceeding of Fourteenth European Peptide Symposium, 471-476 (1976).
Shemyakin, M., et al., Angew Chem., Int. Ed. Engl., 8, 492-499 (1969).

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