Drug – bio-affecting and body treating compositions – Lymphokine
Patent
1992-12-21
1994-05-03
Nucker, Christine M.
Drug, bio-affecting and body treating compositions
Lymphokine
424 93U, 514 23, 514 42, 514 54, 436519, 436524, A61K 3170, A61K 3700, A61K 3900
Patent
active
053086147
ABSTRACT:
The present invention relates to an improved method for the production of antibodies to tumor-associated gangliosides using ganglioside lactones. The resulting antibodies are useful in the detection and treatment of tumors containing gangliosides. The present invention also relates to methods of treatment of tumors by active immunization using ganglioside lactones.
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Livingston et al. P.N.A.S. vol. 84 pp. 2911-2915 May 1987.
Pukel, C. S. et al. J. Exp. med. 155:1133-1147 (1982), "GD3, a prominent ganglioside of human melanoma."
Ravindramath, M. H. et al., Int'l Rev. Immunol. 7:303-329 (1991, "Rule of gangliosides in active immunotherapy with melanoma vaccine."
Dialog Acc. No. 109048445, Edwards, et al.
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Weir, et al. Handbook of Immunol. 1973. pp. 1.1-1.3. Blackwell Sci. Pub.
Cunningham T.
Nucker Christine M.
The Biomembrane Institute
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