Electronic method for autofluorography of macromolecules on two-

Details Electronic method for autofluorography of macromolecules on two- Electronic method for autofluorography of macromolecules on two-

1981-12-30

1983-06-21

Britton, Howard

Facsimile and static presentation processing

Facsimile

Specific signal processing circuitry

235 92PC, 358107, 358211, 250363R, 376159, H04N 718

Patent

active

043896707

ABSTRACT:
A method for detecting, localizing, and quantifying macromolecules contained in a two-dimensional matrix is provided which employs a television-based position sensitive detection system. A molecule-containing matrix may be produced by conventional means to produce spots of light at the molecule locations which are detected by the television system. The matrix, such as a gel matrix, is exposed to an electronic camera system including an image-intensifier and secondary electron conduction camera capable of light integrating times of many minutes. A light image stored in the form of a charge image on the camera tube target is scanned by conventional television techniques, digitized, and stored in a digital memory. Intensity of any point on the image may be determined from the number at the memory address of the point. The entire image may be displayed on a television monitor for inspection and photographing or individual spots may be analyzed through selected readout of the memory locations. Compared to conventional film exposure methods, the exposure time may be reduced 100-1000 times.

REFERENCES:
patent: 4319271 (1982-03-01), Hurni
N. Wade, "The Complete Index to Man," Science, 211, 33-35 (Jan. 2, 1981).
E. P. Lester et al, "Computer Assisted Analysis of Two-Dimensional Electrophoreses of Human Lymphoid Cells," Clinical Chemistry, 26(10), 1392-1412 (1980).
V. W. Arndt et al, "X-ray Television Area Detectors for Macromolecular Structural Studies with Synchrotron Radiation Sources", Journal of Applied Crystalography (1979) 12, pp. 1-9.

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